Clinical Research Directory

Inclusion Criteria: * Aged 18 to 65 years. * Able to provide informed consent and have an adequate command of English. * For participants in the schizophrenia group: diagnosis of schizophrenia according to DSM-5 criteria. * For control participants: no current or past mental disorder. * For control participants: no family history of schizophrenia or psychosis. * No history of head trauma resulting in loss of consciousness. * For female participants: negative pregnancy test. * No history of neurological disorder or past or present neurological illness. * No drug, alcohol, or substance dependence, except nicotine. * No significant medical or physical disorder or illness. * No contraindications to MRI. * Not currently breastfeeding. * No participation in a clinical trial or receipt of an investigational product within 90 days, five half-lives, or twice the duration of the biological effect of the investigational product, whichever is longer. * Negative blood test for glucose-6-phosphate dehydrogenase deficiency. * Not taking an SSRI, MAOI, or other serotonergic drug in the 6 weeks before the study. * No cardiac arrhythmia on screening ECG. * No history of renal failure. * No significant history of heart disease or ECG abnormality.