Clinical Research Directory

Inclusion Criteria: * Maintenance hemodialysis dependent ESRD patients hospitalized for or with volume overload at either MGH or BWH * Received at least one hemodialysis session during the index hospitalization * Meet the following previously published criteria for volume overload: a) Clinical impression of volume overload and/or an acute heart failure exacerbation, or b) Respiratory compromise defined as subjective dyspnea or presenting oxygen saturation \<92% on room air plus \>2 of the following signs: i) Jugular venous distension, ii) Third heart sound, iii) Bibasilar lung rales or crackles, iv) Pulmonary edema on chest imaging, v) Reported bilateral pulmonary infiltrates on chest imaging without fever, vi) Reported pleural effusion on chest imaging, vii) Reported abdominal ascites on abdominal imaging, viii) Documented central venous pressure \>12 mmHg, ix) Documented pulmonary capillary wedge pressure \>12 mmHg Exclusion Criteria: * Patients with acute kidney injury requiring dialysis * Patients hospitalized for the initiation of hemodialysis * Patients requiring continuous kidney replacement therapy at admission * Patients under observation status * Patients with liver cirrhosis