Clinical Research Directory
Browse clinical research sites, groups, and studies.
Osteogenic Potential of Topical Metformin Gel on Cystic Jaw Defects
Sponsor: Fayoum University
Summary
Evaluate the osteogenic effect of locally applied 1% metformin gel on bone volume formation after jaw cystic defects enucleation
Official title: Assessment of Osteogenic Potential of Topical Metformin Gel on Bone Regeneration in Cystic Jaw Defects: Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-10-30
Completion Date
2027-10-30
Last Updated
2026-10-14
Healthy Volunteers
Yes
Interventions
For the Experimental Arm: 1% Metformin Gel
1\. For 1% Metformin Gel (Experimental Arm): Intervention Description: Pure metformin hydrochloride powder is dissolved into a biocompatible, in-situ gelling base at a concentration of 10 mg/ml to prepare a high-viscosity 1% metformin gel. Following surgical enucleation and thorough irrigation of the odontogenic cystic cavity, the gel is applied directly into the residual bony defect to act as a bioactive tissue-engineering matrix.
For the Comparator / Control Arm: Placebo Gel
For Placebo Gel (Comparator Arm): Intervention Description: A visually and physically identical methylcellulose-based placebo gel. Following surgical enucleation and thorough irrigation of the odontogenic cystic cavity, the placebo gel is applied directly into the residual bony defect in an identical manner to maintain double-blinding
Locations (1)
Fayoum University
Al Fayyum, Faiyum Governorate, Egypt