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Randomised Controlled Trial Comparing CD62L and CD45RA Depleted Donor Lymphocyte Infusion With T-cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation
Sponsor: Hong Kong Children's Hospital
Summary
The goal of clinical trial is to compare the efficacy and safety of CD62L depleted donor lymphocyte infusion (DLI) with CD45RA depleted DLI in children who receive T-cell depleted haploidentical hematopoietic stem cell transplantation (HSCT). Participants will be randomised to receive either CD62L depleted DLI or CD45RA depleted DLI with HSCT and evaluate for efficacy and safety outcomes.
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
46
Start Date
2026-10-02
Completion Date
2029-10-01
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
CD62L depleted DLI
CD62L depleted DLI
CD45RA depleted DLI
CD45RA depleted DLI
Haploidentical HSCT
T cell depleted haploidentical HSCT
Locations (1)
Hong Kong Children's Hospital
Hong Kong, Hong Kong