Clinical Research Directory

predictive cohort Inclusion Criteria: * Female, aged 18-65 years, with an expected lifespan of ≥5 years; * Meets the definition of high risk for breast cancer (fulfills at least one criterion): carrier of BRCA1/2 mutations, family history of breast cancer in first-degree relatives, confirmed atypical ductal hyperplasia (ADH/LCIS) through breast biopsy, mammography indicating high glandular density, or previous chest radiotherapy before the age of 30. Exclusion Criteria: * Previous history of breast cancer or other malignant tumors; pregnancy or lactation; * Currently using hormone replacement therapy (HRT) or prophylactic tamoxifen; Abnormal liver and kidney function (ALT/AST \>2 times the upper limit, Cr \>1.5 mg/dL); * Allergic to the components of the sample; * The patient has poor cognitive ability and is unable to answer questions or fill out questionnaires; * The researcher believes that it is not suitable for him/her to participate in this study. prognostic cohort Inclusion Criteria: Female, aged 18-65, with an expected lifespan of ≥5 years; * Pathologically diagnosed as invasive breast cancer with clear molecular typing (ER-positive, HER2-positive, or triple-negative); * Has completed radical treatment for breast cancer during the intensive phase, with no known residual lesions. Exclusion Criteria: * Presence of distant metastasis (stage IV) or local recurrence; * Is currently undergoing chemotherapy, immunotherapy, or experimental drugs (excluding endocrine/targeted therapy); * Plan to undergo major surgery or radiotherapy within the next 6 months; * Pregnancy or lactation; Abnormal liver and kidney function (ALT/AST \>2 times the upper limit, Cr \>1.5 mg/dL); * Allergic to the components of the sample; * The patient has poor cognitive ability and is unable to answer questions or fill out questionnaires; * The researcher deems himself/herself unsuitable for participation in this study.