Clinical Research Directory

Inclusion Criteria: * HbA1c measured within the past 6 months between 5.7% and 6.4%. * eGFR measured within the past 6 months of at least 45 mL/min/1.73 m². * Prediabetes defined by diagnosis code R73.0 or a subcategory. * Age 35 years or older. * BMI of at least 25 kg/m². * Low non-nutritive sweetener use, defined as less than once per week. Exclusion Criteria: * Type 1 diabetes. * Type 2 diabetes. * History of bariatric surgery. * History of organ or tissue transplantation. * Current GLP-1 agonist treatment. * Current metformin treatment. * Current oral steroid medication. * Current immunosuppressant use, including tacrolimus, cyclosporine, mycophenolate mofetil, prednisone, methylprednisolone, sirolimus, or everolimus. * Severe gastrointestinal disease, at the discretion of the PI and physician Co-Investigator. * Severe comorbidities with poor physical or mental function that may prevent completion of study procedures, at the discretion of the PI and physician Co-Investigator. * Current or planned pregnancy or lactation. * Self-reported non-nutritive sweetener allergy or intolerance. * Regular consumption of non-nutritive sweetener products, defined as once per week or more often. * Concurrent participation in another study involving dietary changes, investigational drugs, or microbiome-altering agents.