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NOT YET RECRUITING
NCT07869329
NA

Biomarker Testing to Predict Radiation-Related Heart Disease in Lung Cancer Patients

Sponsor: Duke University

View on ClinicalTrials.gov

Summary

The study will measure serum Pro-N-Cadherin and NT-proBNP (pro B-type natriuretic peptide) levels in adults with non-small cell lung cancer receiving hypofractionated radiation therapy and evaluate whether these biomarkers correlate with radiation dose to the heart, cardiac dysfunction, and adverse cardiac events. Participants will undergo blood collection and echocardiography over a two-year follow-up period.

Official title: Predicting Radiation-induced Cardiac Disease With the Biomarker Serum Pro-N-Cadherin

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2026-11

Completion Date

2030-11

Last Updated

2026-10-09

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Serum Pro-N-Cadherin Biomarker Assessment

Serial blood collection for measurement of Pro-N-Cadherin and NT-proBNP (pro B-type natriuretic peptide) at baseline and follow-up timepoints, with correlation to cardiac radiation dose and outcomes.

DIAGNOSTIC_TEST

Echocardiogram

Participants will undergo two echocardiograms to measure heart function.

Locations (1)

Duke University Medical Center

Durham, North Carolina, United States