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Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis
Sponsor: Rehman Medical Institute - RMI
Summary
Local anesthetic is used to numb a tooth before a root canal treatment. In lower back teeth with irreversible pulpitis (a painful, inflamed tooth nerve), the standard numbing injection near the jaw nerve, called an inferior alveolar nerve block, often does not numb the tooth enough. When this happens, patients may feel pain during treatment, and dentists often give an extra injection beside the tooth. This study compares two numbing medicines used for that extra injection: 4% articaine and 2% lidocaine, both with epinephrine. Articaine is a newer medicine that may pass through bone more easily, but it is not clear whether it works better than lidocaine in this situation. Adults aged 18 to 50 with a painful lower first molar needing a root canal first receive the standard nerve block with lidocaine. Patients who still feel pain when the dentist begins opening the tooth then receive an extra injection beside the tooth, with either articaine or lidocaine. Which medicine is given is decided by chance, and neither the patient nor the dentist knows which one it is.
Official title: Efficacy of Articaine Versus Lidocaine in Supplemental Infiltration for Mandibular First Molars With Symptomatic Irreversible Pulpitis After Failed Inferior Alveolar Nerve Block: A Prospective Randomized Double-Blind Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-03-03
Completion Date
2026-08-27
Last Updated
2026-10-09
Healthy Volunteers
No
Interventions
Articaine 4% with epinephrine 1:100,000
Supplemental buccal infiltration of 1.8 mL of 4% articaine with 1:100,000 epinephrine, given next to the mandibular first molar with a standard aspirating dental syringe and a 30-gauge short needle. It is given only to participants who report pain during access cavity preparation after an inferior alveolar nerve block with 2% lidocaine.
Lidocaine 2% with Epinephrine 1:100,000
Supplemental buccal infiltration of 1.8 mL of 2% lidocaine with 1:100,000 epinephrine, given next to the mandibular first molar with a standard aspirating dental syringe and a 30-gauge short needle. It is given only to participants who report pain during access cavity preparation after an inferior alveolar nerve block with 2% lidocaine.
Locations (1)
Rehman Medical Institute
Peshawar, Pakistan