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Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty
Sponsor: Military Hospital of Tunis
Summary
Yes. For these two fields, I would enter the following in English, based on your study protocol. 1\. Brief Summary Copy and paste: This study aims to compare three thromboprophylaxis regimens in adults undergoing primary total knee arthroplasty: rivaroxaban 10 mg once daily, apixaban 2.5 mg twice daily, and low-molecular-weight heparin (LMWH) once daily. The study will assess venous blood flow in the lower limbs using Doppler ultrasound and determine whether blood flow differs between the three treatment groups. Participants will be randomly assigned to one of the three treatment groups and followed for 28 days after surgery. Doppler ultrasound examinations will be performed at baseline and on Days 7, 15, 21, and 28. Additional assessments will include rehabilitation progress, postoperative bleeding, suspected venous thromboembolism, cardiovascular complications, and other postoperative complications. The study is being conducted at the Department of Anesthesiology, Principal Military Hospital of Instruction of Tunis.
Official title: Direct Oral Anticoagulants (DOACs) Once Daily (OD) Versus Direct Oral Anticoagulants (DOACs) Twice Daily (TD) Versus Low-Molecular-Weight Heparin (LMWH) for Thromboprophylaxis After Primary Total Knee Arthroplasty: A Duplex Ultrasound Assessment
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
138
Start Date
2026-09-15
Completion Date
2027-04-15
Last Updated
2026-10-16
Healthy Volunteers
No
Interventions
Apixaban
Apixaban 2.5 mg twice daily, starting 24 hours after surgery, for 14 days. Participants receive initial LMWH prophylaxis 6 hours after surgery before starting the assigned regimen.
Rivaroxaban
Rivaroxaban 10 mg once daily, starting 24 hours after surgery, for 14 days. Participants receive initial LMWH prophylaxis 6 hours after surgery before starting the assigned regimen.
Enoxaparin (LMWH)
Enoxaparin 40-60 mg once daily, weight-adjusted, starting 6 hours after surgery, for 14 days.
Locations (1)
Principal Military Hospital of Instruction of Tunis
Tunis, Tunis Governorate, Tunisia