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Undenatured Type II Collagen for Knee Osteoarthritis Pain
Sponsor: Universidad Católica San Antonio de Murcia
Summary
This randomized, controlled, double-blind, three-arm parallel clinical trial will evaluate the efficacy and safety of undenatured type II collagen products on joint pain in adults diagnosed with knee osteoarthritis. Participants will be randomized to Nuvicol II, Nuvicol SII, or placebo and will consume one capsule daily for 4 months. Pain, quality of life, knee muscle function, concomitant analgesic medication use, cartilage degradation biomarkers, safety laboratory variables, and adverse events will be assessed during follow-up.
Official title: Randomized Clinical Trial to Analyze the Efficacy and Safety of Undenatured Type II Collagen Product on Joint Pain in Patients Diagnosed With Osteoarthritis
Key Details
Gender
All
Age Range
31 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2027-03
Completion Date
2027-07
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Placebo
Matching placebo capsules containing maltodextrin and magnesium stearate, orally once daily for 4 months.
Nuvicol II
Undenatured type II collagen from chicken source, 40 mg orally once daily for 4 months.
Nuvicol SII
Undenatured type II collagen from salmon source, 40 mg orally once daily for 4 months.
Locations (1)
UCAM HiTech - Unidad de Estudios Clínicos
Murcia, Murcia, Spain