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Nutraceutical Supplementation Combined With Physiotherapy for Rotator Cuff Tendinopathy
Sponsor: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Summary
Rotator cuff tendinopathy is a common cause of shoulder pain and functional impairment. Exercise-based physiotherapy represents a cornerstone of conservative treatment, while nutraceutical supplementation has been proposed as a potential adjunctive strategy. This prospective, randomized, assessor-blinded study evaluated the effects of adding a nutraceutical formulation containing bioactive collagen peptides, astaxanthin, trans-resveratrol, and vitamin C (Doltendix®) to physiotherapy in patients with rotator cuff tendinopathy without partial- or full-thickness tendon tears. Forty-two participants were randomly allocated in a 1:1 ratio to physiotherapy plus nutraceutical supplementation or physiotherapy alone. Pain, shoulder function, upper-limb disability, and health-related quality of life were assessed over a 120-day follow-up period
Official title: Effects of Nutraceutical Supplementation Combined With Physiotherapy in Patients With Rotator Cuff Tendinopathy: A Prospective Randomized Assessor-Blinded Study
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2024-10-03
Completion Date
2025-05-05
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Doltendix®
Oral nutraceutical formulation containing bioactive collagen peptides, astaxanthin, trans-resveratrol, and vitamin C. Participants received two sachets per day after the main meals for the first 10 days, followed by one sachet per day for the subsequent 80 days, for a total supplementation period of 90 days.
Exercise-based Physiotherapy
Participants underwent a 1-month exercise-based physiotherapy program aimed at improving shoulder strength and range of motion. The same physiotherapy program was administered to both treatment groups
Locations (1)
Policlinico Riuniti di Foggia
Foggia, Apulia, Italy