Clinical Research Directory

Inclusion Criteria: * Body mass index (BMI) ≥ 30 kilograms per meter square (kg/m\^2), or BMI ≥ 27 to \< 30 kg/m\^2 with one of the following: * hypertension: treated, or with systolic blood pressure ≥ 130 millimeters of mercury (mmHg) or diastolic blood pressure ≥ 80 mmHg * dyslipidemia: treated or previously diagnosed high cholesterol, high triglycerides, or low HDL cholesterol. * history of obstructive sleep apnea * history of cardiovascular disease * history of fatty liver disease (including metabolic dysfunction-associated steatotic liver disease \[MASLD\] or metabolic dysfunction-associated steatohepatitis \[MASH\]) * At least 1 unsuccessful attempt at weight loss by diet and exercise. * Contraception for females. * Willingness to follow trial procedures for the duration of the trial. Exclusion Criteria: * Obesity induced by other endocrinologic disorders. * Change in body weight \> 5 kg within last 90 days. * Previous or planned surgical, endoscopic, or device-based treatment for obesity. * History of malignancy within the past 5 years. * Type 1 or Type 2 diabetes mellitus. * History of chronic pancreatitis or history of acute pancreatitis within last 180 days. * Family or personal history of medullary thyroid cancer. * Previous participation in a Maridebart Cafraglutide trial.