Clinical Research Directory

Inclusion Criteria: * Complete (AIS A) or incomplete (AIS B) acute traumatic SCI involving bony spinal levels between C0 and T1 (inclusive) * Able to communicate in English and provide informed consent Exclusion Criteria: * History and/or symptoms of cardiovascular disease (Type 2 Diabetes is ok) or cardiopulmonary problems/disease, including uncontrolled hypertension * Traumatic brain injury that is severe enough to preclude neurologic assessment of SCI impairment and assignment of AIS grade A or B. * Aneurysms of the thoracic aorta * Pregnant * Unstable Angina * Myocardial infarction in the preceding 2 days * Aortic stenosis * Any patient who requires additional vasopressor infusions other than NE within 4 hours of the time that the crossover is to be conducted will be excluded and considered a screen-fail (i.e. at the time of the crossover, the participant must only be on norepinephrine for blood pressure control and maintained solely on norepinephrine for the 4 hours preceding the crossover) * Any patient who does not have an arterial line and central venous catheter (CVC) inserted as part of their standard clinical management at the time the crossover is to be conducted will be excluded and considered a screen-fail. * Any other medical condition that in the investigator's opinion would render the study procedures dangerous or impair your ability to receive study therapy