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Glycemic Variability After SASI Versus Roux-en-Y Gastric Bypass
Sponsor: Hospitales Universitarios Virgen del Rocío
Summary
The GLUBARI trial is a prospective, randomized, single-center clinical study comparing two bariatric surgical procedures in adults with morbid obesity: Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass (RYGB). The main objective is to compare glycemic variability between the two procedures using continuous glucose monitoring. Participants will undergo continuous glucose monitoring for 7 days before surgery and again at 6 and 12 months after surgery. Secondary outcomes include hypoglycemic events, weight loss, resolution of obesity-related comorbidities, postoperative complications, gastroesophageal reflux, nutritional deficiencies, and quality of life. A total of 68 participants will be randomized in a 1:1 ratio to SASI or RYGB and followed for 12 months after surgery.
Official title: Comparison of Glycemic Variability After Bariatric Surgery With Single Anastomosis Sleeve Ileal Bypass (SASI) Versus Roux-en-Y Gastric Bypass (RYGB) Using Continuous Glucose Monitoring
Key Details
Gender
All
Age Range
18 Years - 74 Years
Study Type
INTERVENTIONAL
Enrollment
68
Start Date
2026-07-14
Completion Date
2028-07
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Single Anastomosis Sleeve Ileal Bypass
Bariatric surgical procedure consisting of sleeve gastrectomy with a single gastroileal anastomosis.
Roux-en-Y Gastric Bypass
Bariatric surgical procedure consisting of gastric pouch creation with gastrojejunal and jejunojejunal anastomoses.
Locations (1)
Hospital Universitario Virgen del Rocío
Seville, Sevilla, Spain