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Clomiphene Citrate Alone Versus Clomiphene Plus Metformin as First Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome
Sponsor: Independent University Hospital, Pakistan
Summary
This study will compare the effectiveness of clomiphene citrate alone with clomiphene citrate combined with metformin for treating anovulation and infertility in women with polycystic ovary syndrome (PCOS). Women with PCOS who have difficulty becoming pregnant because they do not ovulate regularly will be enrolled in the study. Participants will be assigned to receive either clomiphene citrate alone or clomiphene citrate combined with metformin. The study will compare pregnancy and ovulation outcomes between the two treatment groups to determine whether adding metformin to clomiphene citrate improves the chances of conception in women with PCOS-related anovulatory infertility.
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
218
Start Date
2025-01-01
Completion Date
2025-06-30
Last Updated
2026-10-13
Healthy Volunteers
No
Interventions
Clomiphane citrate + Metformin
Clomiphene citrate was administered as an ovulation-induction treatment, with dose escalation up to 150 mg/day according to the study protocol. It was administered alone in Group B and in combination with metformin in Group A. Participants were followed for six months, and conception was assessed using a urine pregnancy test.
clomiphene citrate alone
Clomiphene citrate was administered as an ovulation-induction treatment, with dose escalation up to 150 mg/day according to the study protocol. Participants received clomiphene citrate alone without metformin and were followed for six months. Conception was assessed using a urine pregnancy test.
Locations (1)
Independent University Hospital
Faisalābad, Punjab Province, Pakistan