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NOT YET RECRUITING
NCT07872774

Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)

Sponsor: University Hospital, Essen

View on ClinicalTrials.gov

Summary

DECIDE-SAH is an international, multicenter, retrospective, observational, non-interventional secondary-use cohort study of adults with aneurysmal subarachnoid hemorrhage (aSAH). The study combines pre-existing routine-care patient-level data from consecutive retrospective aSAH cohorts. Its primary objective is to evaluate the association between decompressive craniectomy (DC) strategies and unfavorable functional outcome approximately 6 months after aSAH, with particular emphasis on exact or best-available ictus-to-DC timing, the neurological context at the treatment decision, the indication for decompression, and technical characteristics of DC. The primary endpoint is modified Rankin Scale (mRS) 4-6 approximately 6 months after ictus. No prospective patient recruitment, study-specific treatment, additional diagnostic procedure, treatment allocation, or patient contact is planned.

Official title: Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage: An International Multicenter Retrospective Patient-Level Cohort Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

10000

Start Date

2026-11

Completion Date

2031-12

Last Updated

2026-10-14

Healthy Volunteers

No

Interventions

PROCEDURE

Decompressive craniectomy

Surgical decompression performed as part of routine clinical care. DECIDE-SAH does not assign or modify treatment. The exposure is characterized by exact or best-available ictus-to-DC timing, the neurological context at the treatment decision, the documented indication for decompression, and technical characteristics including DC type, extent or dimensions where available, and duraplasty. For Primary DC, the relevant clinical context is the baseline/admission or intraoperative status; for Secondary DC, pre-Secondary-DC neurological status is used where available.

Locations (1)

Department of Neurosurgery and Spine Surgery, University Hospital Essen

Essen, North Rhine-Westphalia, Germany