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Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)
Sponsor: University Hospital, Essen
Summary
DECIDE-SAH is an international, multicenter, retrospective, observational, non-interventional secondary-use cohort study of adults with aneurysmal subarachnoid hemorrhage (aSAH). The study combines pre-existing routine-care patient-level data from consecutive retrospective aSAH cohorts. Its primary objective is to evaluate the association between decompressive craniectomy (DC) strategies and unfavorable functional outcome approximately 6 months after aSAH, with particular emphasis on exact or best-available ictus-to-DC timing, the neurological context at the treatment decision, the indication for decompression, and technical characteristics of DC. The primary endpoint is modified Rankin Scale (mRS) 4-6 approximately 6 months after ictus. No prospective patient recruitment, study-specific treatment, additional diagnostic procedure, treatment allocation, or patient contact is planned.
Official title: Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage: An International Multicenter Retrospective Patient-Level Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10000
Start Date
2026-11
Completion Date
2031-12
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
Decompressive craniectomy
Surgical decompression performed as part of routine clinical care. DECIDE-SAH does not assign or modify treatment. The exposure is characterized by exact or best-available ictus-to-DC timing, the neurological context at the treatment decision, the documented indication for decompression, and technical characteristics including DC type, extent or dimensions where available, and duraplasty. For Primary DC, the relevant clinical context is the baseline/admission or intraoperative status; for Secondary DC, pre-Secondary-DC neurological status is used where available.
Locations (1)
Department of Neurosurgery and Spine Surgery, University Hospital Essen
Essen, North Rhine-Westphalia, Germany