Clinical Research Directory

Inclusion Criteria: * Aged 18 to 65 years * Hospitalized in a psychiatric ward in one of the participating centers * French-speaking * Able to understand the study objectives and to give free, informed, signed consent * Affiliated to a social security scheme Inclusion Criteria specific Group 1 (Bipolar At-Risk, without prior manic/hypomanic episode) - defined by one of the following: 1. Subsyndromal hypomania: abnormally and persistently elevated, expansive or irritable mood for at least 2 but fewer than 4 consecutive days, plus at least 2 of: increased self-esteem/grandiosity, decreased need for sleep, increased talkativeness, flight of ideas, distractibility, increased goal-directed activity or psychomotor agitation 2. Depression with cyclothymic features: major depressive episode (DSM-5) plus a history of numerous subsyndromal hypomanic episodes (not meeting criteria of group a) and numerous depressive episodes 3. Depression with genetic risk: major depressive episode (DSM-5) plus a first-degree relative with bipolar disorder Inclusion Criteria specific Group 2 (Diagnosed Bipolar Disorder): bipolar disorder type 1 or 2 diagnosed according to DSM-5, with a history of at least one manic and/or hypomanic episode Exclusion Criteria: * Diagnosis of psychotic disorder (schizophrenia, delusional disorder) * Known intellectual disability or severe autism spectrum disorder (except ADHD) * Confirmed neurodegenerative disorder * Psychiatric syndrome of other organic origin (e.g., head trauma, neurological or endocrine disorder) * Person receiving involuntary psychiatric care * Under guardianship or curatorship * Pregnant, breastfeeding or parturient woman * Person deprived of liberty by judicial or administrative decision0