Clinical Research Directory

Intervention Description: Percutaneous portal vein recanalization (PVR) is a minimally invasive endovascular procedure performed via interventional radiology to restore portal blood flow in pediatric patients with non-cirrhotic extrahepatic portal vein obstruction (EHPVO). The procedure utilizes catheter-based techniques, consisting of balloon angioplasty alone or combined with endovascular stent placement, tailored to individual anatomy. Unlike traditional surgical options (such as Meso-Rex bypass) or non-physiological shunts, PVR re-establishes portal perfusion directly into the native hepatic circulation via a percutaneous route for patients ineligible for or unwilling to undergo surgery. The intervention also includes post-procedural antithrombotic medical therapy. Patients who failed PVR are investigated for alternative treatment strategies including: trans jugular intrahepatic portosystemic shunt (TIPS), Meso-Rex bypass (MRB) and surgical shunts.