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Comparing 10 Hz rTMS and iTBS for Adolescent Depression
Sponsor: Qilu Hospital of Shandong University
Summary
This trial compares two transcranial magnetic stimulation (TMS) protocols-10 Hz rTMS and intermittent theta burst stimulation (iTBS)-in adolescents with major depressive disorder. Eighty participants aged 11-19 years will be randomly assigned to receive either 10 Hz rTMS or iTBS over a two-week period. Clinical symptoms, cognitive function, brain imaging, and neurophysiological measures will be assessed at baseline, immediately post-treatment, and at a 1-month follow-up to evaluate both the immediate and sustained therapeutic effects and underlying mechanisms.
Official title: A Randomized Controlled Trial Protocol Comparing 10 Hz rTMS and iTBS for Adolescent Depression: Clinical Efficacy, Neurocognitive and Neurobiological Mechanisms
Key Details
Gender
All
Age Range
11 Years - 19 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-10-08
Completion Date
2027-12-31
Last Updated
2026-10-14
Healthy Volunteers
No
Interventions
10 Hz Repetitive Transcranial Magnetic
Non-invasive brain stimulation using a figure-of-eight coil to deliver magnetic pulses to the left dorsolateral prefrontal cortex, with individualized neuronavigation-guided coil positioning.
Intermittent Theta Burst Stimulation
Non-invasive brain stimulation using a figure-of-eight coil to deliver magnetic pulses to the left dorsolateral prefrontal cortex, with individualized neuronavigation-guided coil positioning.
Locations (1)
Shandong Mental Health Center
Jinan, Shandong, China