Clinical Research Directory

Inclusion Criteria: * Diagnosis of PCOS according to the Rotterdam criteria, requiring the presence of at least two of the following three features: oligo-ovulation or anovulation; clinical and/or biochemical hyperandrogenism; Polycystic ovarian morphology on ultrasonography. * According to the prespecified study protocol, polycystic ovarian morphology was defined as the presence of ≥12 follicles measuring 2-9 mm in diameter and/or ovarian volume \>10 mL in at least one ovary. * BMI \<30 kg/m². * Documented anovulation, supported by a luteal serum progesterone concentration \<3 ng/mL. * Bilateral tubal patency confirmed by hysterosalpingography. * Absence of another identifiable female infertility factor. * Normal semen analysis of the male partner. Exclusion Criteria: * Persistent hyperprolactinemia. * Congenital adrenal hyperplasia or other adrenal disorders associated with androgen excess. * Pituitary insufficiency. * Clinically significant thyroid dysfunction affecting ovulation. * Previous ovarian surgery. * Use of ovulation-induction agents, insulin-sensitizing medications or other oral hypoglycemic agents, hormonal contraceptives, or anti-androgen medications within 60 days before enrollment. * Known hypersensitivity or contraindication to letrozole or inositol.