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Evaluation of MTHFR Gene Polymorphism and Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis Individuals
Sponsor: Akdeniz University
Summary
This observational study aims to evaluate the relationship between MTHFR gene polymorphisms and periodontal clinical findings in healthy individuals, individuals with hypertension, individuals with periodontitis, and individuals with both hypertension and periodontitis. A total of 200 participants will be included in four groups of 50 participants each. Periodontal clinical measurements, including plaque index, gingival index, bleeding on probing, probing depth, and clinical attachment level, will be recorded. Venous blood samples will be collected for DNA isolation and analysis of MTHFR gene polymorphisms. The study will investigate whether MTHFR gene polymorphisms are associated with periodontal clinical parameters and hypertension.
Official title: Evaluation of MTHFR Gene Polymorphism Along With Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis Individuals
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2026-03-27
Completion Date
2026-09-27
Last Updated
2026-10-14
Healthy Volunteers
Yes
Conditions
Interventions
MTHFR Gene Polymorphism Analysis
Participants will undergo venous blood sampling, DNA isolation, and analysis of MTHFR gene polymorphisms. No therapeutic intervention is assigned to participants; the study is observational.
Locations (1)
Akdeniz University Faculty of Dentistry, Department of Periodontology
Antalya, Antalya, Turkey (Türkiye)