Clinical Research Directory

Inclusion Criteria: 1. 30 - 65 years of age. 2. Diagnosed with periodontitis according to clinical attachment loss (CAL) ≥3 mm at two or more non-adjacent sites and/or probing pocket depth (PPD) ≥4 mm. 3. Diagnosed with dry eye disease that meets 3 out of 4 of the following criteria: Ocular surface disease index score of more than 12, tear film break-up time of 10 s or less, Schirmer test results without anesthesia of less than 10 mm/5 min, and ocular surface staining with more than five corneal spots, more than nine conjunctival spots, or lid margin involvement greater than 2 mm in length and 25% in width. When both eyes fulfilled the criteria, the eye with the more severe disease was selected. If both eyes showed equal severity, one eye was randomly chosen. 4. Possessing more than 20 natural teeth. - Exclusion Criteria: 1. Individuals with diabetes mellitus, uveitis, conjunctivitis, or active ocular allergy. 2. Individuals receiving topical or systemic corticosteroid treatment or immunomodulatory therapy. Those with previous use of ocular medications other than artificial tears. Those who have undergone major ocular surgeries or have undergone ocular surgery in the previous 3 months; those who wear contact lenses; and individuals with proptosis or eyelid abnormalities, as well as individuals with a history of laser-assisted in situ keratomileusis (LASIK) surgery. 3. Smokers. 4. Received periodontal treatment and antibiotics within the past 3 months 5. Individuals with autoimmune diseases. 6. Individuals who are pregnant and/or lactating. 7. Individuals whose occupations involve prolonged screen exposure. -