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A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Sjögren's disease (SjD).
Official title: A Phase 1, Multicenter, Open-Label Study of BMS-986553, CD19 In Vivo Chimeric Antigen Receptor (CAR) T Cells, in Participants With Refractory Autoimmune Diseases
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10-30
Completion Date
2033-01-31
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
BMS-986553
Specified dose on specified days
Locations (23)
Local Institution - 0064
Newport Beach, California, United States
Local Institution - 0001
Worcester, Massachusetts, United States
Local Institution - 0004
Ann Arbor, Michigan, United States
Local Institution - 0013
Saint Paul, Minnesota, United States
Local Institution - 0062
Omaha, Nebraska, United States
Local Institution - 0007
Morristown, New Jersey, United States
Local Institution - 0052
Great Neck, New York, United States
Local Institution - 0008
Philadelphia, Pennsylvania, United States
Local Institution - 0015
Salt Lake City, Utah, United States
Local Institution - 0005
Seattle, Washington, United States
Local Institution - 0003
Seattle, Washington, United States
Local Institution - 0029
Leuven, Belgium
Local Institution - 0039
Montpellier, France
Local Institution - 0047
Paris, France
Local Institution - 0028
Berlin, Germany
Local Institution - 0060
Erlangen, Germany
Local Institution - 0059
Magdeburg, Germany
Local Institution - 0027
Würzburg, Germany
Local Institution - 0055
Amsterdam, North Holland, Netherlands
Local Institution - 0063
Leiden, Netherlands
Local Institution - 0051
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Local Institution - 0050
Krakow, Malopolwksie, Poland
Local Institution - 0046
Poznan, Poland