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Can Adjunctive Oral Magnesium Supplementation Prolong the Effect of Botulinum Toxin Type A in Excessive Gingival Display?
Sponsor: Cairo University
Summary
To evaluate and compare the effect of adjuvant oral magnesium supplementation combined with Botulinum Toxin Type A versus Botulinum Toxin Type A alone on the reduction of millimeter gingival display and the duration of clinical effectiveness in patients with excessive gingival display
Official title: Can Adjunctive Oral Magnesium Supplementation Prolong the Effect of Botulinum Toxin Type A in Patients With Excessive Gingival Display? A Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2026-10-01
Completion Date
2027-10-30
Last Updated
2026-10-14
Healthy Volunteers
No
Interventions
Oral Magnesium Glycinate capsules
Oral Supplement: Oral Magnesium Glycinate capsules (300 mg elemental magnesium daily, single or divided dose taken with meals). Supplementation starts 4 weeks prior to BoNT-A injection (Day -28) to achieve intracellular steady-state repletion and continues for 4 weeks post-injection (through Day 28), totaling 8 consecutive weeks (56 days) of daily intake
● BoNT-A Injection Alone (Day 0)
BoNT-A Injection Alone (Day 0): Identical administration protocol (2.5 Units per side bilaterally at the Yonsei Point, total 5.0 Units) delivered by the same experienced operator without any oral supplementation.
Locations (1)
Cairo University
Cairo, Egypt