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Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
Sponsor: Ahmed Adel Ahmed Elsayed Ali Radwan
Summary
PURPOSE: To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. BACKGROUND: Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes (Brown et al., 2022; Caan et al., 2018). High-load resistance training is often poorly tolerated in this population (Schmitz et al., 2019). Although low-load resistance training with blood flow restriction shows promise, CRC-specific randomized evidence remains limited (Patterson et al., 2019; Arnold et al., 2017). HYPOTHESES: It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance, and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. RESEARCH QUESTION: Does low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance, and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
Official title: LOW LOAD BLOOD FLOW RESTRICTION RESISTANCE TRAINING IN COLORECTAL CANCER RELATED SARCOPENIA
Key Details
Gender
All
Age Range
40 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2026-05-17
Completion Date
2027-12-20
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
Low load blood flow restriction resistance training
Low-load resistance training combined with blood flow restriction using pneumatic cuffs applied to the proximal lower limb at 60% arterial occlusion pressure. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.
Low load resistance training without Blood Flow Restriction
Low-load resistance training without blood flow restriction. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.
Locations (1)
Private Clinics
Cairo, Egypt