Clinical Research Directory

Inclusion Criteria: * Planning to undergo ventral hernia repair * CT scan available within the past 6 months, demonstrating ventral hernia transverse defect size \>8 centimeters (cm) or loss of domain (defined as Tanaka index \[hernia sac volume:abdominal cavity volume\] of 0.25 or greater) Exclusion Criteria: * Use of any anticoagulant or antiplatelet medications is an absolute exclusion criterion. No holding protocol exists for these medications, and patients currently taking any of the following agents are ineligible regardless of the ability to temporarily discontinue: aspirin (any dose), Plavix, clopidogrel, ticagrelor, prasugrel, dipyridamole, cilostazole, dabigatran, rivaroxaban, apixaban, warfarin, or enoxaparin. * Neuromuscular disorders * Thrombocytopenia, elevated international normalized ratio (INR), and/or elevated partial thromboplastin time (PTT) outside of normal lab value range * Unable to provide informed consent to participate in the study Such as a mental condition rendering the participant unable to understand the nature, scope, and possible consequences of the study * Pregnant or breast-feeding women or those who plan to become pregnant during the study * Women of childbearing potential not protected by effective contraceptive method of birth control and/or who are unwilling or unable to be tested for pregnancy. * Patients with accepted contraindication to cryoneurolysis procedure including local site infection, cryoglobulinemia, or Raynaud's disease * Presence of systemic infections * Anatomical derangements that may prevent procedural success * Individuals with needle phobias * Patients with an implanted electronic device such as a pacemaker or defibrillator should not undergo the procedure unless approved by a medical specialist.