Clinical Research Directory

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged 18 or older * Diagnosed with either acute pancreatitis, recurrent acute pancreatitis or chronic pancreatitis as defined by the American Pancreatic Association. * Currently smoking cigarettes daily or on most days, with an average of ≥5 cigarettes/day over the past 30 days. * Explicitly express a desire to quit within 30 days * Ability to take oral medication and be willing to adhere to the study intervention regimen * Willing and able to comply with trial protocol and follow-up Exclusion Criteria: * Age \< 18 years of age. * No desire to quit smoking within 30 days. * Known hypersensitivity to varenicline * Active seizure disorder or other medical condition judged by the investigator to make varenicline unsafe. * History of chronic kidney disease (creatinine clearance \< 30 mL/minute) * Current untreated psychotic disorder or acute manic episode that would interfere with participation or safe medication use. * Unable to provide informed consent.