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Dexmedetomidine Infusion and Iscemia and Reperfusion Injury
Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital
Summary
The effect of deksmedetomidine infusion on ischemia-reperfusion injury related to tourniquet application during total knee replacement will be evaluated by malondialdehyde and total antioksidant status.
Official title: The Effect of Dexmedetomidine Infusion on Turniquet Induced Iscemia and Reperfusion Injury in Total Knee Replacement Surgery
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2015-12
Completion Date
2016-04
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
0.1 mcg/kg/min 10 minutes dexmedetomidine infusion followed by 0.2-0.7 mcg/kg/hour dexmedetomidine infusion
saline
0.1 mcg/kg/min 10 minutes saline infusion followed by 0.2-0.7 mcg/kg/hour saline infusion