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An Online Tailored Cognitive Therapy-Based Intervention for Depression in Multiple Sclerosis: ACTION-MS Online
Sponsor: University of Melbourne
Summary
Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons. Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual. The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.
Official title: A Randomized Controlled Trial of an Online Tailored Cognitive Therapy Based Intervention For Depression in Multiple Sclerosis: ACTION-MS Online
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-11-01
Completion Date
2027-06-30
Last Updated
2026-10-15
Healthy Volunteers
No
Interventions
ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression.
The CBT-based online intervention is designed for people with multiple sclerosis who are experiencing mild to moderate depression. There are 8 modules which include (1) Introduction; (2) Managing depressive and anxiety symptoms: Part 1; (3) Managing depressive and anxiety symptoms: Part 2; (4) Practice challenging unhelpful thoughts; (5) Managing fatigue and pain; (6) Sleep hygiene; (7) Problem Solving; (8) Preventing relapse of depressive and anxiety symptoms.
The 'Health and Wellbeing in MS' website
The 'Health and Wellbeing in MS' website contains health information related to MS. There are 8 sections of the website with each section focusing on a different topic. Each section includes information and some key evidence from current research about the topic. The 8 sections are: (1) Nutrition and diet; (2) Gut health and microbiome; (3) Supplements; (4) Vitamin D and sun exposure; (5) Lipids and MS; (6) Weight and obesity; (7) Smoking; (8) Other health conditions and MS.
Locations (2)
Royal Melbourne Hospital
Melbourne, Victoria, Australia
MS Barlo Centre, St Michael's Hospital
Toronto, Canada