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Comparison of the Therapeutic Effects of Lyophilized Platelet-rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis
Sponsor: Taichung Veterans General Hospital
Summary
The goal of this clinical trial is to compare the therapeutic effects of lyophilized platelet-rich plasma lysate and dextrose prolotherapy in patients with knee osteoarthritis (OA). The main questions it aims to answer are: * Does lyophilized platelet-rich plasma lysate improve pain, physical function, and muscle strength in patients with knee osteoarthritis? * Is lyophilized platelet-rich plasma lysate more effective than dextrose prolotherapy in improving clinical outcomes in patients with knee osteoarthritis? Researchers will compare patients receiving lyophilized platelet-rich plasma lysate with those receiving dextrose prolotherapy to evaluate differences in treatment effectiveness. Participants will: * Receive intra-articular injections of either lyophilized platelet-rich plasma lysate or dextrose prolotherapy. * Undergo clinical assessments before and after treatment, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to evaluate pain, stiffness, and physical function. * Undergo knee X-ray examinations to assess osteoarthritis severity using the Kellgren-Lawrence (KL) grading system. * Undergo isokinetic muscle strength testing using a Biodex dynamometer to evaluate knee muscle strength.
Official title: Comparison of the Therapeutic Effects of Lyophilized Platelet-Rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
39
Start Date
2024-01-01
Completion Date
2026-07-22
Last Updated
2026-10-15
Healthy Volunteers
No
Interventions
Lyophilized Platelet-rich Plasma Lysate
Lyophilized platelet-rich plasma lysate is an autologous platelet-derived preparation obtained from participants' peripheral blood. Approximately 130 mL of blood will be collected and processed using multiple centrifugation steps to isolate and concentrate platelets. The platelets will then be activated and lysed to release growth factors and other bioactive components, followed by lyophilization to produce a freeze-dried preparation. After sterility testing, participants in the intervention group will receive intra-articular injections of PRP Plus into the affected knee once monthly for three consecutive months, for a total of three injections.
Dextrose Prolotherapy
Dextrose prolotherapy is an injection-based treatment using a hypertonic dextrose solution. Participants assigned to the control group will receive dextrose injections into the affected knee as an active comparator to lyophilized platelet-rich plasma lysate. The treatment aims to alleviate knee pain and improve joint function in patients with knee osteoarthritis. Participants will receive intra-articular injections once monthly for three consecutive months, for a total of three injections.
Locations (1)
Taichung Veterans General Hospital
Taichung, Taiwan