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Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
Sponsor: Tanta University
Summary
The goal of this clinical trial is to compare methotrexate injections with triamcinolone acetonide injections for treating nail psoriasis. Nail psoriasis can cause nail pitting, discoloration, thickening, and separation of the nail from the skin underneath. The study will also compare the safety of these treatments. The main questions it aims to answer are: * Which treatment produces greater improvement in nail psoriasis? * What side effects do participants experience with each treatment? Researchers will compare methotrexate with triamcinolone acetonide. Both medications will be injected intralesionally into the affected nail area. Participants will: * Receive intralesional injections according to the study treatment plan. * Attend clinic visits to assess changes in their affected nails and check for side effects. * Report any pain, discomfort, or other medical problems experienced during the study.
Official title: Single Blinded Left to Right Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
Key Details
Gender
All
Age Range
16 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2023-05-01
Completion Date
2025-06-15
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
Methotrexate
Methotrexate at a concentration of 25 mg/mL will be injected intralesionally into the affected nail area on one side of each participant. Injections will be given every two weeks for a maximum of six sessions or until improvement.
Triamcinalone Acetonide
Triamcinolone acetonide at a concentration of 10 mg/mL will be injected intralesionally into the affected nail area on the side opposite to that receiving methotrexate. Injections will be given every two weeks for a maximum of six sessions or until improvement.
Locations (1)
Tanta University Hospital,Department of Dermatology and Venereology
Tanta, Gharbia Governorate, Egypt