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Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2
Sponsor: Washington University School of Medicine
Summary
In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to assess additional psychometric properties such as test re-test reliability and practice effects. Investigators will obtain data on: A) clinical symptoms, with detailed assessment of hallucinations and delusions; B) community functioning; and C) functional capacity, allowing us to examine clinical validity. To generate a sample with sufficient variation in hallucinations and delusions, investigators will recruit the following groups that balance feasibility with clinical relevance: A) healthy controls \[HC, N=125\]; B) schizophrenia and schizoaffective disorder \[SZ/SZA, N=200\]). Investigators anticipate a \~20% screen fail/drop-out rate based upon prior studies. Thus, investigators will run an additional 40 SZ/SZA and 15 HC. Investigators will administer tasks optimized in Aim 1 without electroencephalogram (EEG), to this new sample of individuals with SZ/SZA and HC. All participants will be retested after approximately 28 days and repeat clinical assessments. Although the investigators' goal is to shorten task length using the Study 1 analyses, they will administer longer tasks than optimal for public dissemination in Study 2 to determine the minimum number of trials required for acceptable reliability. Study 2 will use the same clinical and functional measures as Study 1.
Official title: Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium
Key Details
Gender
All
Age Range
18 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
325
Start Date
2028-04
Completion Date
2031-06-30
Last Updated
2026-10-15
Healthy Volunteers
Yes
Interventions
Motion Perception Task
Assesses updating of beliefs from new sensory inputs with prior knowledge via perceiving direction changes in random dot motion stimuli
Sine Wave Speech Task
Measures the degree to which overweighting of prior beliefs impacts processing of sensory inputs (detection of speech).
Volatility Task
Measures the updating of priors about the location of a bag drop from a helicopter when the location changes (prediction errors).
Choice Probabilistic Reversal Task
Assesses prior belief updating when feedback about obtaining positive outcomes changes (prediction errors).
Kamin Blocking Task
Examines the role of mismatches between learned priors and new information (prediction errors) in belief formation about event causes.
Minnesota Trust Game
Assesses the degree to which people distinguish between their priors about others' motivations, such as selfishness and spite, and impersonal chance in one-shot trust game and dictator games.
Dynamic Trust Game
Assesses degree to which people learn and update priors about trusting partners from dynamic social feedback (prediction error) in a social exchange game.
Locations (5)
University of California Irvine
Irvine, California, United States
The University of Chicago
Chicago, Illinois, United States
University of Maryland, Baltimore
Baltimore, Maryland, United States
University of Minnesota
Minneapolis, Minnesota, United States
Washington University
St Louis, Missouri, United States