Clinical Research Directory

Inclusion Criteria: * 1\. Systemically healthy adult patients aged 18 to 50 years. 2. Presence of bilateral, symmetrical physiological gingival hyperpigmentation (Dummett Oral Pigmentation Index score \>= 2) requiring esthetic treatment. 3\. Good oral hygiene status (Plaque Index \<= 1). 4. Patients willing and able to comply with trial protocols, oral hygiene instructions, daily diary recording, and scheduled follow-up visits. 5\. Signed written informed consent obtained prior to study enrollment. Exclusion Criteria: * 1\. Smokers or patients using any form of tobacco/nicotine products. 2. Pregnant, lactating, or planning pregnancy during the trial period. 3. Systemic diseases affecting wound healing or bone metabolism (e.g., uncontrolled diabetes mellitus, autoimmune disorders). 4\. History of systemic long-term medications (e.g., corticosteroids, immunosuppressants, anticoagulants, or NSAIDs). 5\. Known allergy or hypersensitivity to sesame oil, beeswax, beta-sitosterol, or any components of MEBO ointment. 6\. Severe periodontitis or active local oral infection/inflammation at the surgical site. 7\. Previous gingival depigmentation procedures performed at the target site within the past 12 months.