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Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation
Sponsor: Hüseyin Ulaş Pinar
Summary
This prospective, randomized, single-center study will compare sevoflurane inhalational anesthesia with propofol intravenous anesthesia in patients undergoing intracardiac echocardiography-guided radiofrequency catheter ablation for atrial fibrillation. Eligible participants will be randomly assigned to one of two general anesthesia groups. In the sevoflurane group, anesthesia will be maintained with sevoflurane, while in the propofol group, anesthesia will be maintained with propofol administered using target-controlled infusion. In both groups, anesthesia depth will be adjusted to maintain a Bispectral Index value between 40 and 60. The study will evaluate acute procedural success and atrial arrhythmia recurrence at 6 months. Additional outcomes will include mapping time, ablation time, total procedure time, hemodynamic instability, recovery score, and procedural complications.
Official title: Comparison of Inhalational Anesthesia and Intravenous Anesthesia as General Anesthesia Management in Intracardiac Echocardiography-Guided Radiofrequency Catheter Ablation Procedures in Patients With Atrial Fibrillation in Terms of Acute Procedural Success and Early Atrial Arrhythmia Recurrence
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2026-10-01
Completion Date
2027-04
Last Updated
2026-10-16
Healthy Volunteers
No
Conditions
Interventions
Sevoflurane
Sevoflurane will be used for maintenance of general anesthesia. General anesthesia will be induced with propofol 2 mg/kg, and the sevoflurane dose will be adjusted to maintain a Bispectral Index (BIS) value between 40 and 60.
propofol
Propofol will be administered using target-controlled infusion (TCI), with an initial plasma target concentration of 4 mcg/mL. General anesthesia will be maintained with propofol, adjusted to maintain a Bispectral Index (BIS) value between 40 and 60.
Locations (1)
Hacettepe University Faculty of Medicine, Department of Anesthesiology and Reanimation
Ankara, Ankara, Turkey (Türkiye)