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NOT YET RECRUITING
NCT07877116
PHASE4

Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation

Sponsor: Hüseyin Ulaş Pinar

View on ClinicalTrials.gov

Summary

This prospective, randomized, single-center study will compare sevoflurane inhalational anesthesia with propofol intravenous anesthesia in patients undergoing intracardiac echocardiography-guided radiofrequency catheter ablation for atrial fibrillation. Eligible participants will be randomly assigned to one of two general anesthesia groups. In the sevoflurane group, anesthesia will be maintained with sevoflurane, while in the propofol group, anesthesia will be maintained with propofol administered using target-controlled infusion. In both groups, anesthesia depth will be adjusted to maintain a Bispectral Index value between 40 and 60. The study will evaluate acute procedural success and atrial arrhythmia recurrence at 6 months. Additional outcomes will include mapping time, ablation time, total procedure time, hemodynamic instability, recovery score, and procedural complications.

Official title: Comparison of Inhalational Anesthesia and Intravenous Anesthesia as General Anesthesia Management in Intracardiac Echocardiography-Guided Radiofrequency Catheter Ablation Procedures in Patients With Atrial Fibrillation in Terms of Acute Procedural Success and Early Atrial Arrhythmia Recurrence

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

124

Start Date

2026-10-01

Completion Date

2027-04

Last Updated

2026-10-16

Healthy Volunteers

No

Interventions

DRUG

Sevoflurane

Sevoflurane will be used for maintenance of general anesthesia. General anesthesia will be induced with propofol 2 mg/kg, and the sevoflurane dose will be adjusted to maintain a Bispectral Index (BIS) value between 40 and 60.

DRUG

propofol

Propofol will be administered using target-controlled infusion (TCI), with an initial plasma target concentration of 4 mcg/mL. General anesthesia will be maintained with propofol, adjusted to maintain a Bispectral Index (BIS) value between 40 and 60.

Locations (1)

Hacettepe University Faculty of Medicine, Department of Anesthesiology and Reanimation

Ankara, Ankara, Turkey (Türkiye)