Clinical Research Directory

Inclusion Criteria: 1. Able to understand and voluntarily sign a written informed consent form, which must be signed prior to the performance of the designated study procedures required by the study. 2. Age ≥ 18 years both male and female. 3. Karnofsky Performance Status Score (KPS) ≥ 70%. 4. Expected survival ≥ 6 months. 5. According to RECIST v1.1, there is at least one measurable lesion that is suitable for repeated and accurate measurements. 6. Histologically or cytologically, pathologically confirmed renal cancer with a clear cell carcinoma component (ccRCC). 7. Locally advanced or metastatic RCC not amenable to curative surgery or radiotherapy. 8. Adequate organ function. Exclusion Criteria: 1. Locally advanced disease that is resectable or suitable for local therapy with curative intent. 2. Histologically or cytologically confirmed renal non-clear cell carcinoma (nccRCC). 3. Presence of active central nervous system (CNS) metastases. 4. Previous anti-tumor therapy toxicity has not been resolved. 5. Have other malignancies within 5 years prior to enrollment. 6. Known presence of active pulmonary tuberculosis and active syphilis infection. 7. Other reasons for ineligibility as evaluated by investigator.