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Antioxidant Supplementation and Muscle Recovery From DOMS in Trained Women
Sponsor: Antonio Molina Lopez
Summary
This randomized, placebo-controlled, parallel-group trial investigated the effects of combined antioxidant and anti-inflammatory supplementation on delayed onset muscle soreness (DOMS) recovery in trained women. Sixty trained women (18-35 years) were randomized into four groups: G1 (Creatine + Omega-3), G2 (Creatine + Omega-3 + NAC), G3 (Creatine + Omega-3 + NAC + CoQ10), and G4 (Placebo). Outcomes included muscle pain pressure threshold, countermovement jump, handgrip strength, 30-meter sprint, bilateral dynamometry, infrared thermography, creatine kinase, and heart rate variability, assessed before and after an eccentric exercise protocol.
Official title: Dose-escalating Antioxidant Supplementation and Neuromuscular Recovery From Exercise-induced Muscle Damage in Trained Women: a Four-arm Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-02-19
Completion Date
2026-04-23
Last Updated
2026-10-16
Healthy Volunteers
Yes
Interventions
Creatine Monohydrate
Creatine monohydrate administered at 5 g/day for 4 weeks. Used in G1, G2, and G3 arms
Omega 3 FA (Fish Oil)
Administered as 2 capsules/day (456 mg EPA + 225 mg DHA per capsule; EPA:DHA ratio 2:1) for 4 weeks. Included in G1, G2, and G3 arms.
N-Acetyl Cysteine (NAC)
Administered at 600 mg/day for 4 weeks. Included in G2 and G3 arms.
Coenzyme Q10 100 MG Oral Capsule
Administered at 100 mg/day for 4 weeks. Included in G3 arm only.
Placebo
Maltodextrin (5 g/day) and olive oil capsules (2 capsules/day), visually identical to active arms. Administered for 4 weeks in G4 arm.
Locations (1)
Diego
Madrid, Spain