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Tissue Repositioning Versus Tissue Support in Thread Lifting for Nasolabial Fold Correction: A Randomized, Evaluator-Blinded, Parallel-Group Controlled Trial
Sponsor: Beijing Tsinghua Chang Gung Hospital
Summary
This randomized clinical trial compares two minimally invasive thread-lifting procedures for improving moderate-to-severe nasolabial folds, the lines that run from the sides of the nose toward the corners of the mouth. Both procedures use absorbable threads placed under the skin, but they differ in their main treatment approach. One procedure is designed primarily to lift and reposition sagging facial tissues, whereas the other is designed primarily to provide local support and added volume beneath and around the folds. Approximately 180 adults with moderate-to-severe nasolabial folds will be randomly assigned to one of the two treatment groups. An independent evaluator who does not know the treatment assignment will assess changes in the nasolabial folds during follow-up. The main purpose of the study is to compare the effectiveness of the two procedures 7 months after treatment. The study will also assess early improvement, participants' and evaluators' overall impressions of the results, and treatment-related adverse events and safety.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
182
Start Date
2022-06-21
Completion Date
2023-11-20
Last Updated
2026-10-16
Healthy Volunteers
No
Conditions
Interventions
predominantly tissue-repositioning thread lifting
A predominantly tissue-repositioning and multi-plane tissue-lifting thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
predominantly tissue-support thread-lifting
A predominantly tissue-support and multiregional volumization thread-lifting protocol for correction of moderate-to-severe nasolabial folds.
Locations (1)
Beijing Tsinghua Changgung Hospital
Beijing, China