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Comparison of Segmental Body Composition Characteristics in Lipedema and Obesity
Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Summary
The aim of this study is to compare the total and regional body composition characteristics of women with lipedema and women without lipedema who are matched for age and body mass index, as determined by the TANITA MC-580 segmental bioelectrical impedance analysis (BIA) device. In addition to total fat mass and fat percentage, fat mass, fat-free mass, and muscle mass measurements of the right and left legs, right and left arms, and trunk are planned to be evaluated. From these measurements, regional distribution indicators such as the proportion of lower extremity fat mass within total body fat, the leg-to-trunk fat ratio, the leg-to-arm fat ratio, and the leg muscle-to-fat ratio will be calculated. In addition, the study aims to examine the relationships between segmental body composition characteristics and disease type and stage, disease duration, pain severity, and lower extremity function in the lipedema group. Hypothesis: The proportion of total body fat located in the lower extremities is significantly higher in women with lipedema compared to women without lipedema matched for age and body mass index.
Official title: Comparison of Segmental Body Composition Characteristics in Lipedema and Obesity: A Body Mass Index-Matched Bioelectrical Impedance Analysis Study
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2026-09-20
Completion Date
2026-12-30
Last Updated
2026-10-16
Healthy Volunteers
Yes
Interventions
Bioelectrical Impedance Analysis
Body composition will be assessed using bioelectrical impedance analysis. Total and segmental body composition parameters, including body fat mass, body fat percentage, muscle mass, and total body water, will be recorded.
Numeric Rating Scale
Pain intensity will be evaluated using the Numeric Rating Scale, ranging from 0 (no pain) to 10 (worst imaginable pain).
Lower Extremity Functional Scale
Functional status will be assessed using the Lower Extremity Functional Scale. The total score ranges from 0 to 80, with higher scores indicating better lower extremity function and lower disability levels.
Short Form-12
Health-related quality of life will be assessed using the SF-12 questionnaire, including the Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores. Scores range from 0 to 100, with higher scores indicating better perceived health status and quality of life.
Clinical Staging
Lipedema stage will be determined according to clinical examination findings and established diagnostic criteria.
Locations (1)
Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Uskudar
Istanbul, Uskudar, Turkey (Türkiye)