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Sequential Digital Intervention to Increase Influenza Vaccination in Patients With Heart Failure
Sponsor: Heart Health Research Center
Summary
Influenza vaccination is an important preventive measure for patients with heart failure (HF), but vaccination uptake remains low in China. Although previous studies have demonstrated the benefits of actively promoting influenza vaccination, scalable strategies to improve vaccination uptake among patients with HF after hospital discharge remain insufficiently evaluated. The PANDA-BOOST trial is a prospective, pragmatic, open-label, two-stage sequential randomized clinical trial involving participants previously enrolled in the PANDA II trial. The study aims to evaluate whether sequential digital interventions using artificial intelligence (AI)-assisted telephone calls and short message service (SMS) reminders improve influenza vaccination uptake compared with a single routine vaccination recommendation. After an initial AI-assisted telephone call providing a standardized influenza vaccination recommendation, eligible unvaccinated participants will be randomized in a 1:2 ratio to a routine recommendation group or a sequential digital intervention group. Participants in the sequential intervention group will receive additional AI-assisted telephone calls approximately 14 and 28 days after the initial call. Those who remain unvaccinated and meet eligibility criteria at the third call will undergo a second randomization in a 1:1:1 ratio to no additional SMS, gain-framed SMS, or loss-framed SMS. The primary outcome is influenza vaccination uptake within two months after the first-stage randomization.
Official title: A Sequential Digital Intervention to Increase Influenza Vaccination Uptake in Patients With Heart Failure: The PANDA-BOOST Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
588
Start Date
2026-10-15
Completion Date
2026-12-31
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
Routine Influenza Vaccination Recommendation
A single standardized influenza vaccination recommendation is provided during the initial AI-assisted telephone call before first-stage randomization. The call also assesses contact status, survival status, and current-season vaccination status.
Repeated AI-Assisted Telephone Intervention
Participants assigned to the sequential digital intervention strategy receive additional AI-assisted telephone calls approximately 14 and 28 days after the initial call. Vaccination status is reassessed, and unvaccinated participants are asked about reasons for non-vaccination and receive a repeated vaccination recommendation. Further intervention is discontinued for participants confirmed to have been vaccinated.
Gain-Framed SMS Reminder
One gain-framed SMS message emphasizing the potential health protection associated with influenza vaccination is sent approximately 14 days after second-stage randomization to participants assigned to this strategy.
Loss-Framed SMS Reminder
One loss-framed SMS message emphasizing the potential loss of protection and continued influenza-related health risks associated with non-vaccination is sent approximately 14 days after second-stage randomization to participants assigned to this strategy.
Locations (1)
Ruyang Rural Health Institute
Ruyang, Henan, China