Clinical Research Directory

Inclusion Criteria: * Males and females between 18 and 70 years of age, inclusive. * Availability for the full duration of the study visit. * Good general health without conditions posing risk during dental procedures. * Willingness to provide medical history and sign Informed Consent and Privacy Notice forms. * Minimum of 20 uncrowned permanent natural teeth (excluding third molars and artificial crowns). * At least 80% of tooth sites with visible supragingival plaque. * Less than 10% of tooth sites with visible supragingival calculus. * Less than 30% of tooth sites with pocket depth (PD) and clinical attachment level (CAL) \> 5 mm. Exclusion Criteria: * Presence of gross oral mucosal pathology. * Uncontrolled systemic chronic disease (e.g., uncontrolled diabetes) or conditions interfering with host immune response. * Use of anti-inflammatory drugs or antibiotics within 3 months prior to study start, or scheduled use during study. * Use of therapeutic mouthwashes within 3 months prior to study start. * Requirement for antibiotic prophylaxis prior to dental procedures. * Current participation in any other clinical study. * Pregnant, breastfeeding, or intending to become pregnant during the study. * Known allergy to oral care products, personal care consumer products, or their ingredients. * Ongoing use of medications known to affect gingival tissues (e.g., calcium channel blockers, phenytoin, cyclosporine). * Current smokers or history of alcohol or substance abuse. * Presence of orthodontic appliances or fixed/removable prosthodontic dentures. * Presence of carious lesions requiring immediate restorative treatment. * Professional dental cleaning (oral prophylaxis) within 1 month prior to study enrollment.