Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Impact of Long-term High-risk Drinking on the Effective Dose of Osselidin
Sponsor: Affiliated Hospital of Jiaxing University
Summary
this study aims to investigate the effect of chronic high-risk alcohol consumption on the effective dose of oliceridine combined with propofol for painless gastroscopy, so as to provide a reference for rational clinical medication.
Official title: The Impact of Long-term High-risk Drinking on the 90% Effective Dose of Osselidin in Adult Males Undergoing Painless Gastroscopy
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-10-15
Completion Date
2026-12-20
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
long-term high-risk drinking
If a patient had failed gastroscope insertion, the next patient would receive a higher dose (an increasing of 1.5 μg/kg). However, if a patient had successful gastroscpe insertion, the next patient would receive a lower dose (a decreasing of 1.5 μg/kg) with a probability of approximately B ≈ 0.11 (i.e., 1/9), or the same dose with a probability of 1 - B = 0.89 (i.e., 8/9). The initial dosage of oliceridine was set at 13 μg/kg, with an up-down dose of 1.5 μg/kg, based on our hospital's experience and findings in the literature.
non-drinking
If a patient had failed gastroscope insertion, the next patient would receive a higher dose (an increasing of 1.5 μg/kg). However, if a patient had successful gastroscpe insertion, the next patient would receive a lower dose (a decreasing of 1.5 μg/kg) with a probability of approximately B ≈ 0.11 (i.e., 1/9), or the same dose with a probability of 1 - B = 0.89 (i.e., 8/9). The initial dosage of oliceridine was set at 13 μg/kg, with an up-down dose of 1.5 μg/kg, based on our hospital's experience and findings in the literature.
Locations (1)
Affiliated Hospital of Jiaxing University
Jiaxing, Zhejiang, China