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Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension Laryngoscopy
Sponsor: The First Hospital of Jilin University
Summary
This is a single-center, prospective, single-blinded, randomized controlled trial conducted at The First Hospital of Jilin University. A total of 134 adult patients aged 18-65 years with ASA Ⅰ-Ⅲ undergoing elective laryngoscopic surgery for vocal cord polyps will be enrolled. Subjects will be randomly assigned into two groups. The control group receives intranasal dexmedetomidine plus intravenous normal saline before anesthesia induction. The combination group receives the same dose of intranasal dexmedetomidine plus intravenous esketamine before induction. The primary objective is to compare the incidence of emergence agitation within 60 minutes after extubation. Secondary outcomes include hemodynamic changes, adverse events, recovery time, PACU stay, postoperative sore throat pain and quality of recovery at 24 hours. Standardized anesthesia induction and maintenance will be applied for all patients. The study aims to explore whether the combination of intranasal dexmedetomidine and esketamine improves recovery quality in patients undergoing suspension laryngoscopy.
Official title: Effect of Dexmedetomidine Nasal Spray Combined With Esketamine on the Quality of Recovery in Patients Undergoing Suspension Laryngoscopy Surgery
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
134
Start Date
2026-09
Completion Date
2026-12
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidin
Dexmedetomidine will be administered intravenously before anesthesia induction in both groups.
Esketamine
Esketamine will be administered intravenously before anesthesia induction only in the intervention group.
Locations (1)
The First Hospital of Jilin University
Ch’ang-ch’un, China