Clinical Research Directory

Inclusion Criteria: Patients: * Aged 15 to 60 years at inclusion * Already assessed in a FondaMental expert centre or a First Episode Psychosis (PEP) / RHU PsyCare centre * Signed informed consent (and consent of parents/legal guardians for minors, or of the curator for adults under curatorship) * Confirmed DSM-5 diagnosis at inclusion of at least one of the following: * Non-specific first-episode psychosis\* * Schizophrenia * Bipolar disorder * Major depressive disorder (recurrent or treatment-resistant) * Autism spectrum disorder without intellectual disability * Clinical condition compatible with clinical, biological and imaging assessments * Affiliated with or beneficiary of a social security scheme * Women of childbearing potential: negative blood or urine pregnancy test at inclusion * Agrees to be informed of any abnormality detected on MRI \*Non-specific first-episode psychosis: patients aged 35 or younger, with significant functional impairment (SOFAS), presenting at least two concurrent psychotic symptoms (e.g., hallucinations, delusions, disorganisation) or a first onset of a psychotic disorder (ICD-10 F20-F29) or mood disorder with psychotic features (ICD-10 F30-F39), with the episode lasting more than 7 days and first frank psychotic symptoms having appeared less than 2 years ago. Healthy volunteers (matched to patients by sex and 10-year age group): * Aged 18 to 60 years at inclusion * Signed informed consent * No personal or first-degree family history, in the past 5 years, of: non-specific first-episode psychosis, schizophrenia, bipolar disorder, recurrent or treatment-resistant depressive disorder, or autism spectrum disorder without intellectual disability * No current prescription of antidepressant, antipsychotic, mood stabiliser or psychostimulant for a characterised disorder * No use of antidepressant, antipsychotic, mood stabiliser or psychostimulant in the past 5 years * Condition compatible with clinical, biological and imaging assessments * Affiliated with or beneficiary of a social security scheme * Women of childbearing potential: negative blood or urine pregnancy test at inclusion * Agrees to be informed of any abnormality detected on MRI Exclusion Criteria: Patients: * Unstabilised somatic or psychiatric condition * Contraindication to MRI * Emergency situation, inability to give consent, or under judicial protection (sauvegarde de justice) * Pregnant or breastfeeding women * Refusal to be informed of any abnormality detected on MRI Healthy volunteers: * Psychiatric disorder in the past 5 years (screened with the MINI interview) * Unstabilised somatic condition * Contraindication to MRI * Inability to give consent * Pregnant or breastfeeding women * Refusal to be informed of any abnormality detected on MRI