Clinical Research Directory
Browse clinical research sites, groups, and studies.
Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery
Sponsor: Bucharest Emergency Hospital
Summary
This study aims to evaluate whether monitoring perioperative inflammatory and metabolic biomarkers can help identify postoperative complications early in adult patients undergoing colorectal or gastric cancer surgery. The study is a randomized controlled trial conducted at Bucharest Emergency Clinical Hospital, Romania. Participants are assigned to either an intervention group receiving enhanced recovery care (ERAS) combined with perioperative biomarker monitoring or a control group receiving standard postoperative care. The biomarkers of interest include procalcitonin, lactate, and blood glucose. The study will examine their relationship with postoperative complications, particularly infections and anastomotic leakage. Participants will be followed for 30 days after surgery to assess postoperative complications, hospital length of stay, readmissions, and mortality. The findings may help improve postoperative monitoring and support earlier recognition of complications in patients undergoing cancer surgery.
Official title: Temporal Profiles of Inflammatory Markers in General Oncologic Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
320
Start Date
2026-02-25
Completion Date
2029-01
Last Updated
2026-10-19
Healthy Volunteers
No
Interventions
Perioperative Biomarker-Guided Monitoring
Participants allocated to the experimental group will undergo perioperative biomarker monitoring integrated into an Enhanced Recovery After Surgery (ERAS) protocol. Biomarker assessments will include preoperative blood lactate and glucose measurements, postoperative lactate and procalcitonin measurements at 12 hours, and additional procalcitonin assessments on postoperative days 3, 5, and 7. Biomarker results will be evaluated alongside clinical findings to support postoperative monitoring and early recognition of complications, particularly infections and anastomotic leakage. Participants will be followed for 30 days after surgery to assess postoperative complications, hospital length of stay, readmissions, and mortality.
Locations (1)
Emergency Clinical Hospital Bucharest
Bucharest, Bucharest, Romania