Clinical Research Directory

Inclusion Criteria: * Adults aged between 22 and 35 years, at the start of their orthodontic treatment, with fully erupted permanent dentition. * Presence of at least one maxillary or mandibular canines and/or premolar with a clinically significant rotation (\>10o) that is considered suitable for correction with clear aligner therapy. * Mild to moderate crowding or spacing compatible with comprehensive clear aligner treatment, with no need for extractions. * Good general and oral health without any active periodontal disease or untreated caries, requiring urgent care. * Patient complaint to willingly wear and able to comply with the aligner wear instructions, follow-up appointments, and study procedures, including digital scanning and patient-reported outcome assessments. Exclusion Criteria: * Previous orthodontic treatment within the past 5 years, as this is likely to affect tooth movement response or complicate measurement. * Patients with rotated teeth (canines or premolars) restored with onlays, inlays, or ceramic crowns or extensive restorations that would make it difficult to access or reliably bond attachments to the occlusal surface. * Need for adjunctive orthodontic appliances (e.g.: Temporary Anchorage Devices (TADs), fixed appliances) that would confound interpretation of the attachments' rotational effect during the T0 to Ti phase. * Requirement for extractions as part of the planned aligner treatment, particularly involving the premolars or adjacent teeth. * Active periodontal disease, significant root resorption, or other oral pathologies that contraindicate orthodontic tooth movement. * Systemic conditions or medications known to affect bone metabolism or orthodontic tooth movement (e.g. bisphosphonates, long-term use of corticosteroids). * Poor anticipated compliance (e.g.: inability to attend scheduled visits, unwillingness to wear aligners as instructed) as judged by the investigator.