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Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant

Tundra lists 1 Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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ACTIVE NOT RECRUITING

NCT04692181

SYN-004 Safety and Tolerability in Allo-HCT Subjects

Study Objectives: 1. To evaluate the safety and tolerability of oral SYN-004 in adult allogeneic HCT (allo-HCT) recipients who develop fever after conditioning therapy and are treated with IV β-lactam antibiotics meropenem (MER), piperacillin tazobactam (PIP/TAZO), or cefepime (FEP). 2. To evaluate potential absorption of oral SYN-004 into the systemic circulation of allo-HCT recipients and potential SYN-004-mediated alterations to systemic levels and efficacy of IV MER, PIP/TAZO or FEP. 3. To evaluate potential protective effects of SYN-004 on the intestinal microbiome of allo-HCT recipients treated with IV MER, PIP/TAZO or FEP. 4. To obtain preliminary information on potential therapeutic benefits and patient outcomes of SYN-004 in allo-HCT recipients treated with IV MER, PIP/TAZO or FEP

Gender: All

Ages: 18 Years - Any

Updated: 2026-03-17

1 state

Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant

Prevention of CDI in Adult Patients Being Treated With IV Beta-lactam Antibiotics