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Advanced Thyroid Carcinoma

Tundra lists 1 Advanced Thyroid Carcinoma clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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RECRUITING

NCT07068542

Sacituzumab Tirumotecan Combined With Immunotherapy in Advanced Thyroid Cancer

This is a multicenter, open-label, multi-cohort Phase II exploratory study designed to evaluate the efficacy and safety of sacituzumab tirumotecan with or without tislelizumab in patients with unresectable, locally advanced, or metastatic anaplastic thyroid carcinoma (ATC), poorly differentiated thyroid carcinoma (PDTC), or radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Patients with ATC will receive sacituzumab tirumotecan in combination with tislelizumab. Patients with PDTC and RAIR-DTC will receive sacituzumab tirumotecan monotherapy. The primary objective in the ATC cohort is overall survival (OS). In the PDTC and RAIR-DTC cohorts, the primary objective is progression-free survival (PFS) assessed by investigators per RECIST v1.1.

Gender: All

Ages: 18 Years - Any

Updated: 2026-02-24

1 state

Advanced Thyroid Carcinoma

Radioiodine-refractory Differentiated Thyroid Cancer

Poorly Differentiated Thyroid Carcinoma