Clinical Research Directory
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2 clinical studies listed.
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Tundra lists 2 Alpha-1 Antitrypsin Deficiency (AATD) clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07227207
A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)
This is a Phase 1/2, open-label, multi-center, dose escalation (Part 1), dose expansion (Part 2), and single repeat dose (Part 3) study to evaluate the safety, tolerability, efficacy, and PK/PD parameters of TSRA-196 in adults with the PiZZ genotype who have lung and/or liver disease associated with severe alpha-1 antitrypsin deficiency (AATD)
Gender: All
Ages: 18 Years - 70 Years
Updated: 2025-11-12
NCT07193615
Study of YOLT-202 in the Treatment of Alpha-1 Antitrypsin Deficiency (AATD)
This is a single-arm, open-label, single-dose, dose-escalation exploratory study to evaluate the safety and tolerability of a single dose of YOLT-202 in patients with AATD and determine the optimal biologically active dose (OBD) of YOLT-202.
Gender: All
Ages: 18 Years - 70 Years
Updated: 2025-09-26