Clinical Research Directory

PREDICTORS OF TESTOSTERONE DECLINE IN MIDDLE-AGED MEN

Age-related decline in testosterone levels in men is associated with multiple metabolic, functional and psychosocial consequences. Early identification of modifiable factors associated with decreased testosterone levels may contribute to improved prevention of androgen deficiency and related health conditions. This population-based observational cross-sectional study aims to investigate morphometric, functional and lifestyle factors associated with decreased total testosterone levels in middle-aged men. Approximately 650-800 men aged 35-55 years residing in the Andijan region of Uzbekistan will be recruited. Participants will undergo comprehensive assessment including anthropometric measurements, functional performance tests, standardized questionnaires evaluating lifestyle factors and laboratory determination of serum total testosterone levels. Morphometric variables will include body mass index, waist circumference, hip circumference and waist-to-hip ratio. Functional status will be assessed using hand-grip strength, chair-stand test, balance assessment and the six-minute walk test. Lifestyle factors including physical activity, sleep habits, dietary patterns and harmful habits will be evaluated using validated questionnaires. The study aims to identify predictors of decreased testosterone levels and develop a predictive model for early identification of androgen deficiency in middle-aged men.

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women with chronic back pain treated with opioids who have low testosterone.

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and overground walking) in men with testosterone deficiency and walking dysfunction after incomplete or complete spinal cord injury. The investigators hypothesize that LT+TRT treatment will improve muscle size and bone mineral density in men with low T and ambulatory dysfunction after incomplete or complete SCI, along with muscle fundtion and walking recovery in men with T low and ambulatory dysfunction ater incomplete SCI.