Clinical Research Directory

Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy

Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence comparing anesthetic strategies in ankle arthroscopy is limited. This multicenter randomized trial compares total intravenous anesthesia with propofol plus peripheral nerve block (PNB), general anesthesia plus PNB, and spinal anesthesia, with PACU-I recovery time as the primary outcome. Secondary outcomes include postoperative pain, opioid consumption, hospital length of stay, adverse events, recovery quality, satisfaction, limb weakness, and intraoperative hemodynamics.

A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery

Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Minimally Invasive Ankle Surgery: A Noninferiority Randomized Clinical Trial Purpose This study aims to compare the pain control effect and side effects of non-opioid versus opioid medications in patients undergoing ankle arthroscopy. The goal is to find a safer analgesic strategy to reduce opioid use and related risks (e.g., addiction, respiratory depression) while maintaining effective postoperative pain management. Design Study Type: Prospective, randomized controlled trial. Participants: 110 adults (18-65 years) scheduled for ankle arthroscopy and Mini-open ankle surgery under general anesthesia. Interventions: Experimental Group: Non-opioid regimen (celecoxib + acetaminophen). Control Group: Opioid regimen (oxycodone + acetaminophen). Assessments: Pain scores (NRS) at 2 hours,6 hours,12 hours, 24 hours, and days 2-6 postoperatively; Area under the curve (AUC\\\_{0-24}) of Numerical Rating Scale (NRS) pain intensity scores from 0-24 hours.adverse events (e.g., nausea, constipation); The total consumption of additional rescue opioids, expressed as oral morphine equivalent dose (OME); patient satisfaction. Key Eligibility Able to provide informed consent. ASA physical status I-II. BMI 16-32 kg/m². Exclusion criteria: Chronic pain, opioid use history, allergies to study drugs, or severe organ dysfunction. Benefits \& Risks Benefits: Standardized analgesia management and personalized pain monitoring; potential contribution to safer clinical pain protocols. Risks: Opioids may cause nausea, sedation, or respiratory depression; non-opioids may carry risks of gastrointestinal bleeding or liver injury. Emergency support is available for severe events. Contact Information For more details, contact the research team at Zhejiang University Second Affiliated Hospital: Phone: 0571-87783759 Email: keyanlunli\_zheer@163.com This trial is registered to evaluate non-opioid alternatives for ankle arthroscopy pain control, prioritizing patient safety and evidence-based care.

EQUISOCK: New Antiequine

The goal of this experimental study is to test the feasibility and validity of a new orthosis in patients with ankle lesions (external popliteal sciatic nerve or nerve injuries resulting in loss of ankle dorsiflexion) of both sexes and all ages. The main question it aims to answer is:Is the new orthosis a support for ankle stability??Does the new orthosis improve ankle function and patients' quality of life??The control group will be the subjects themselves when wearing their conventional ankle orthosis or without it. Participants must wear the new ankle orthosis for at least one month to assess the effectiveness of the orthosis and evaluate any changes that have occurred in the ankle joint and muscles.

Effect of Different Kinesio Band Applications on Balance, Ankle Function and Jump

This research is a scientific research and is about "Effect of Different Kinesio Band Applications on Balance, ankle function and jump". Foot and ankle injuries are one of the most common problems among musculoskeletal injuries. Various methods are used to prevent and treat such injuries. In this study, it is aimed to evaluate the effectiveness of these applications by examining the effects of different kinesio band applications on balance, ankle function and jump. Personal information such as name, surname, height, weight will be obtained by asking the participant. The body mass index will be calculated by dividing the size of the size of the size of the length of the height. Different Kinesio band applications will be made to the participants and the effects of these applications will be evaluated. The equilibrium ability of the participants will be evaluated by Modified Star Excursion Balance Test). Foot and ankle functions In the evaluation, a questionnaire of 29 questions will be used. The jump performance will be determined by measuring the horizontal leap distances of the participants. In this study, the participants will be appointed to random groups. This randomness will be provided by using a system called Randomizer.org over the internet. Thus, each participant will be equal to the chances of being included in one of the 3 different band applications. This method allows the study to be conducted impartially and fairly. All evaluations and practices to be made within the scope of this research do not contain an invasive (surgery, needle, etc.) procedure and no risk or discomfort is foreseen for the participants. However, due to kinesio band applications, temporary effects may occur such as sensitivity or allergic reaction in the skin. If such a situation occurs, the tape will be removed immediately and necessary measures will be taken.

French Ankle Ligament Surgery Cohort Study

This 20-year cohort study foolows patients after ankle ligament reconstruction surgery to evaluate re-rupture rates, long term functional outcomes, return to sport rates ans complications? The goal is to provide insights into the procedure's durability and effectiveness to enhance patient care.